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  1. Review 2: "Severity of Illness Caused by Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern in Children: A Single-Center Retrospective Cohort Study"

    This preprint offers a retrospective analysis evaluating correlations between SARS-CoV-2 Variants of Concern and disease severity in children. The study finds that neither alpha or delta variants were associated with severe COVID-19 symptoms. Reviewers deemed the study reliable.

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  2. Review 1: "Severity of Illness Caused by Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern in Children: A Single-Center Retrospective Cohort Study"

    This preprint offers a retrospective analysis evaluating correlations between SARS-CoV-2 Variants of Concern and disease severity in children. The study finds that neither alpha or delta variants were associated with severe COVID-19 symptoms. Reviewers deemed the study reliable.

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  3. Strength of evidence

    Reviewers: Francisco José Sanz-Santaeufemia( Hospital Infantil Universitario Niño Jesús) | 📗📗📗📗◻️
    Alfredo Tagarro (Fundacion para la Investigacion Biomedica del Hospital Universitario 12 de Octubre) | 📗📗📗📗◻️

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  4. SciScore for 10.1101/2021.10.23.21265402: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The Lurie Children’s Institutional Review Board approved this study (IRB 2020-3792).
    Sex as a biological variablenot detected.
    RandomizationTwice monthly, approximately 25-50% of samples meeting these criteria are randomly selected for WGS.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Using residual diagnostic samples from pediatric inpatients and outpatients who tested positive by SARS-CoV-2 polymerase chain reaction (PCR) in our clinical microbiology laboratory, we perform surveillance for SARS-CoV-2 variants using whole genome sequencing (WGS) with the Center for Pathogen Genomics and Microbial Evolution at Northwestern University.
    WGS
    suggested: None
    Statistical analyses were performed using Stata/IC 16.0 (StataCorp, College Station, TX) and R version 4.1.0.
    StataCorp
    suggested: (Stata, RRID:SCR_012763)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study has several limitations. As a single-center study, our findings may not be generalizable to other geographic locations and patient populations. However, the referral area for our hospital in Chicago extends throughout the city and suburban areas and includes a diverse patient base in terms of demographics and medical complexity. These findings should be confirmed in other pediatric and adult populations. Further, the relatively small sample size and rarity of severe outcomes in children contributed to wide CIs, reducing the precision of the effect estimates for the association between the gamma VOC and severe COVID-19 outcomes. This study was limited to those infections for which SARS-CoV-2 was able to be sequenced, biasing the study to inclusion of infections associated with relatively low cycle thresholds (i.e., high viral loads). Although we performed multivariable analyses, it is possible that unmeasured confounding has contributed to our findings. Although we limited our definition of high risk for COVID-19 complications to those for which there are high-quality and reproducible data (i.e., meta-analysis, systematic review, or observational study; not small studies, case reports/series, or conflicting evidence) per CDC classification. (Table S2),8 these data are predominantly from adult populations and may not all apply to children. Nonetheless, based on our observations of COVID-19 severity being strongly associated with, and sometimes mutually inclusive with...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

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