Comparing lateral flow testing with a rapid RT-PCR method for SARS-CoV-2 detection in the UK

Oct 13, 2021

SciScore for 10.1101/2021.10.08.21264742: (What is this?)

Please note, not all rigor criteria are appropriate for all manuscripts.

Table 1: Rigor

Ethics	IRB: This study was reviewed and approved by the Micropathology Ltd Ethics Committee Review Board composed of Professor Sheila Crispin (MA, VetMB, DVA, DVOphthal, DipEVCO, FRCVS), Professor Christopher Dowson (BSc, PhD), Rt Hon Countess of Mar, Most Rev Dr Gordon Mursell (MA, Hon DD) and William NH Taylor (BTech)). Consent: No additional consent was necessary.
Sex as a biological variable	not detected.
Randomization	not detected.
Blinding	not detected.
Power Analysis	not detected.

Table 2: Resources

Software and Algorithms
Sentences	Resources
Statistical analysis: Probit regression (MedCalc) was used to determine the LLoD (with 95% confidence interval) of both methods.	MedCalc suggested: (MedCalc, RRID:SCR…

SciScore for 10.1101/2021.10.08.21264742: (What is this?)

Please note, not all rigor criteria are appropriate for all manuscripts.

Table 1: Rigor

Ethics	IRB: This study was reviewed and approved by the Micropathology Ltd Ethics Committee Review Board composed of Professor Sheila Crispin (MA, VetMB, DVA, DVOphthal, DipEVCO, FRCVS), Professor Christopher Dowson (BSc, PhD), Rt Hon Countess of Mar, Most Rev Dr Gordon Mursell (MA, Hon DD) and William NH Taylor (BTech)). Consent: No additional consent was necessary.
Sex as a biological variable	not detected.
Randomization	not detected.
Blinding	not detected.
Power Analysis	not detected.

Table 2: Resources

Software and Algorithms
Sentences	Resources
Statistical analysis: Probit regression (MedCalc) was used to determine the LLoD (with 95% confidence interval) of both methods.	MedCalc suggested: (MedCalc, RRID:SCR_015044)
The correlation between viral load and LFD result was calculated in Excel by first converting the LFD results into a score of 0-3 reflecting the number of replicates with a positive result.	Excel suggested: None

Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

Results from TrialIdentifier: No clinical trial numbers were referenced.

Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

Results from JetFighter: We did not find any issues relating to colormaps.

Results from rtransparent:

Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
No protocol registration statement was detected.

Results from scite Reference Check: We found no unreliable references.

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