1. SciScore for 10.1101/2021.10.08.21264719: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: Ethics Statement: The study was conducted in accordance with the general ethical principles as enunciated in the Declaration of Helsinki (1996) and in conformance with International Conference on Harmonisation (ICH) Good Clinical Practice (GCP) guidance and applicable Health Authority and local requirements regarding Institutional Review Boards, Independent Ethics Committees, informed consent, and other statutes or regulations related to the rights and welfare of human subjects participating in biomedical research.
    Consent: Ethics Statement: The study was conducted in accordance with the general ethical principles as enunciated in the Declaration of Helsinki (1996) and in conformance with International Conference on Harmonisation (ICH) Good Clinical Practice (GCP) guidance and applicable Health Authority and local requirements regarding Institutional Review Boards, Independent Ethics Committees, informed consent, and other statutes or regulations related to the rights and welfare of human subjects participating in biomedical research.
    Sex as a biological variablenot detected.
    RandomizationTrial Design: The study was designed to have two phases: an open-label lead-in phase and a randomized placebo-controlled phase.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    The analyses were conducted with NONMEM software.
    NONMEM
    suggested: (NONMEM, RRID:SCR_016986)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    NCT04573322RecruitingSafety and Efficacy of Trans Sodium Crocetinate (TSC) in SAR…


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • No funding statement was detected.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

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