Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations
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SciScore for 10.1101/2021.10.04.463014: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication Authentication: The regression plots for statewise allele frequency Vs the CFR were constructed using https://www.graphpad.com/quickcalcs/linear1/ and further validated by the Microsoft excel regression calculations. Table 2: Resources
Software and Algorithms Sentences Resources PLINK 1.9 was used to extract sequences from the dataset for different populations (14). PLINKsuggested: (PLINK, RRID:SCR_001757)Network v5 and network publisher were employed to draw the median-joining network while total and prevalent haplotypes in TMPRSS2 gene for each … SciScore for 10.1101/2021.10.04.463014: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication Authentication: The regression plots for statewise allele frequency Vs the CFR were constructed using https://www.graphpad.com/quickcalcs/linear1/ and further validated by the Microsoft excel regression calculations. Table 2: Resources
Software and Algorithms Sentences Resources PLINK 1.9 was used to extract sequences from the dataset for different populations (14). PLINKsuggested: (PLINK, RRID:SCR_001757)Network v5 and network publisher were employed to draw the median-joining network while total and prevalent haplotypes in TMPRSS2 gene for each population were calculated using XML file generated through Arlequin 3.5 (18,20). Arlequinsuggested: (ARLEQUIN, RRID:SCR_009051)The regression plots for statewise allele frequency Vs the CFR were constructed using https://www.graphpad.com/quickcalcs/linear1/ and further validated by the Microsoft excel regression calculations. Microsoft excelsuggested: (Microsoft Excel, RRID:SCR_016137)We also performed Pearson’s correlation coefficient test (48) at a 95 percent confidence interval and 1,000 bootstrapping (2,000,000 seeds) for a two-tailed significance test to verify our results by using, SPSS (ver 26). SPSSsuggested: (SPSS, RRID:SCR_002865)The LD map and aggregate frequency of haplotypes carrying rs2070788 (G allele) were calculated for each of the populations by Haploview (49). Haploviewsuggested: (Haploview, RRID:SCR_003076)Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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