“Epidemiological profile of patients with stage 5 chronic kidney disease on dialysis with Covid 19 infection in a Public Hospital-Perú”

  1. Yanissa Venegas-Justiniano
  2. César Loza-Munarriz
  3. Abdías Hurtado-Aréstegui

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Abstract

Introduction

Chronic kidney disease (CKD) in Covid 19 is relevant, however, there are few descriptions and fewer in Peru. Our goal was to describe the epidemiological profile and the factors related to mortality and survival of patients with stage 5 (CKD) on chronic dialysis hospitalized for Covid-19 in a public hospital.

Methods

Retrospective case series. Patients with stage 5 CKD, older than 18 years, hospitalized for Covid-19 infection were included. The primary data source was medical records. The clinical and epidemiological profile of the study sample and the factors related to mortality and survival are described.

Results

105 medical records of patients with CKD 5 were evaluated. 57 (54,29%) were male, with a mean age of 58,59 ± 14,3 years. 84 (80%) patients survived and 21 (20%) died. The main cause of admission to hospitalization was respiratory failure in (80) 76,2%. The hospital stay was 11,76 ± 7,8 days. In the bivariate analysis: the increase in leukocytes, D dimer, ferritin, CRP, LDH and the decrease in lymphocytes, pH, bicarbonate and PaO 2 /FiO 2 were related to mortality. In the multivariate analysis, only CRP> 10 mg/dl [HR: 10.72 (95% CI 1,4-81,58)] and a PaO 2 /FiO 2 ≤ 150 mmHg [HR: 44,40 (95% CI 5,86-336,06)] they were factors related to poor survival.

Conclusions

CRP levels> 10mg/dl and PaO 2 /FiO 2 ≤ 150 mmHg are the main factors related to mortality and poor survival in patients with stage 5 CKD hospitalized for Covid-19.

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  1. ScreenIT

    SciScore for 10.1101/2021.09.30.21264132: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: Ethical Aspects: The Institutional Ethics and Research Committee of the Cayetano Heredia Peruvian University approved the study under the number 039-01-21 and since it is a retrospective study, it is exempt from informed consent.
    Consent: Ethical Aspects: The Institutional Ethics and Research Committee of the Cayetano Heredia Peruvian University approved the study under the number 039-01-21 and since it is a retrospective study, it is exempt from informed consent.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    The main limitations of the study lie in the type of design; it is a retrospective case series whose primary source of data is the hospital medical records, which implicitly may entail a series of errors in the validity and reliability of the data recorded. The biochemical and blood gas variables were processed by the hospital laboratory; they could also have a great intrinsic variability of the values since the variability of the observers and of the equipment used to process the blood samples is unknown.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1101/2021.09.30.21264132v1 on medRxiv