In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a nomothetic network approach

  1. Michael Maes
  2. Walton Luiz Del Tedesco Junior
  3. Marcell Alysson Batisti Lozovoy
  4. Mayara Tiemi Enokida Mori
  5. Tiago Danelli
  6. Elaine Regina Delicato de Almeida
  7. Alexandre Mestre Tejo
  8. Zuleica Naomi Tano
  9. Edna Maria Vissoci Reiche
  10. Andréa Name Colado Simão

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Abstract

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  1. Version published to 10.1038/s41380-021-01431-4
  2. ScreenIT

    SciScore for 10.1101/2021.09.26.21264127: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The protocol was approved by the Institutional Research Ethics Committee of the University of Londrina, Paraná, Brazil (CAAE:31656420.0.0000.5231) and all of the participants and their giardians were informed in detail about the research and gave written informed consent.
    Consent: The protocol was approved by the Institutional Research Ethics Committee of the University of Londrina, Paraná, Brazil (CAAE:31656420.0.0000.5231) and all of the participants and their giardians were informed in detail about the research and gave written informed consent.
    Sex as a biological variablePatients of both sexes who were over the age of eighteen were eligible.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    High sensitivity C-reactive protein (CRP) levels were assayed using turbidimetry (Architect C8000, Abbott Laboratory, Abbott Park, IL, USA).
    Abbott Laboratory
    suggested: None
    IBM SPSS Windows version 25, 2017 was used for statistical analysis.
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Limitations: It would have been more informative if we had measured NLRP3 cytokines such as IL-1β and IL-18, and caspase 1.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.09.26.21264127v1 on medRxiv