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  1. Review 2: "Non-invasive Vagus Nerve Stimulation for Respiratory Symptoms of COVID-19: Results From a Randomized Controlled Trial (SAVIOR I)"

    This preprint claims that nVNS therapy has the potential to reduce pro-inflammatory cytokines in patients with COVID-19. Both reviewers agree on the importance of the issues it raised. They suggested the inclusion of cost-effectiveness analysis in the ongoing SAVIOR II trial.

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  2. Review 1: "Non-invasive Vagus Nerve Stimulation for Respiratory Symptoms of COVID-19: Results From a Randomized Controlled Trial (SAVIOR I)"

    This preprint claims that nVNS therapy has the potential to reduce pro-inflammatory cytokines in patients with COVID-19. Both reviewers agree on the importance of the issues it raised. They suggested the inclusion of cost-effectiveness analysis in the ongoing SAVIOR II trial.

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  3. Strength of evidence

    Reviewers: Abrahão Fontes Baptista (Federal University of ABC) | 📒📒📒◻️◻️
    Claire-Marie Rangon (Hospital Foundation Adolphe De Rothschild) | 📗📗📗📗◻️

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  4. SciScore for 10.1101/2021.09.24.21264045: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The clinical research plan was reviewed and approved by an institutional review board and an ethics committee before patient enrollment.
    Consent: All patients provided written informed consent before participation.
    Sex as a biological variablenot detected.
    RandomizationParticipants: This prospective randomized controlled study was conducted at Hospital Clínico Universitario de Valencia (Valencia, Spain).
    Blindingnot detected.
    Power AnalysisStatistical Analyses: As this was the first study of nVNS for the treatment of patients hospitalized with COVID-19, there are no previously published data on the anticipated effect size in humans, and a formal power analysis could not be performed.

    Table 2: Resources

    Antibodies
    SentencesResources
    As the pandemic progressed, treatment protocols evolved to incorporate glucocorticoids, antivirals, monoclonal antibodies, and prone mechanical ventilation.
    antivirals,
    suggested: None
    Software and Algorithms
    SentencesResources
    Statistical analyses were performed with SAS 9.4 (SAS Institute Inc.).
    SAS Institute
    suggested: (Statistical Analysis System, RRID:SCR_008567)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    NCT04368156Active, not recruitingStudy Assessing Vagus Nerve Stimulation in CoViD-19 Respirat…
    NCT04382391Active, not recruitingStudy Assessing Vagus Nerve Stimulation in CoViD-19 Respirat…


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

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