Article activity feed

  1. Review 2: "Comparison of adverse events between COVID-19 and Flu Vaccines"

    Preprint presents analysis of COVID-19 & flu vaccine-related adverse events using VAERS. Reviewers found results potentially informative in showing effects of the vaccines, but there are limitations to the dataset, the study has flawed methods, and findings are not actionable.

    Read the original source
    Was this evaluation helpful?
  2. Review 1: "Comparison of adverse events between COVID-19 and Flu vaccines"

    Preprint presents analysis of COVID-19 & flu vaccine-related adverse events using VAERS. Reviewers found results potentially informative in showing effects of the vaccines, but there are limitations to the dataset, the study has flawed methods, and findings are not actionable.

    Read the original source
    Was this evaluation helpful?
  3. Was this evaluation helpful?
  4. SciScore for 10.1101/2021.09.22.21263711: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Data preprocessing and descriptive analyses were conducted using R version 4.0.2, running in RStudio Version 1.2.5033.
    RStudio
    suggested: (RStudio, RRID:SCR_000432)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    As mentioned previously, the interpretation of the results is subjected to limitations of passive surveillance system. Moderna had the highest number of reports in VAERS among all cohorts. Most of the reports were from the 31-64 age group which is likely due to the initial authorization of vaccine for the 31-64 age group. The proportion of reports were equally divided among having recovered and not recovered from the adverse event across all cohorts. The proportion of death across COVID vaccines cohorts were comparable and may indicate the high fatality rate of the disease rather than the vaccines especially given that the COVID-19 vaccines were recently introduced and those with severe symptoms had earlier access to them than the general population. Across the five cohorts and age groups, common adverse events could be summarized as: central neuropathy, fever, headache, injection site, nonspecific musculoskeletal pain, chest pain. Except for chest pain, most of the adverse events were already identified in randomized controlled clinical trials of COVID-19 vaccines. Our study provides an age-wise distribution of adverse events as reported in the VAERS database (Table 2). It is hoped that this information will assist some in overcoming their vaccine hesitancy due to safety concerns. Investigating rare side effects of any vaccine is a difficult task[28] due to the rarity of some side-effects, the longer period of manifestation for some side-effects, and lack of evidence for cau...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

    Read the original source
    Was this evaluation helpful?