1. SciScore for 10.1101/2021.09.09.21263251: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The study was approved by the local ethics committee of CHUSJ and performed in the respect of the Helsinki declaration.
    Consent: As such, the study was considered by the ethical committee as exempt from the need to take specific written informed consent from the patients enrolled.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    Statistical analysis was performed using SPSS from IBM, USA.
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study has several limitations. Its retrospective and non-interventional nature limited the availability of follow-up samples with pre-established time-points. The lack of asymptomatic COVID19-positive patients precluded additional comparisons. Additionally, the COVID-19-negative individuals presented with heterogeneous clinical manifestations. Nevertheless, the large and well-defined cohort allowed the confirmation that COVID-19 causes more marked decreases in serum iron and increases in serum ferritin than other pathologies. More importantly, our data consolidate low serum iron, low transferrin, and high IL-6 as important predictors of disease severity in COVID-19.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

    Read the original source
    Was this evaluation helpful?