Investigating vaccine-induced immunity and its effect in mitigating SARS-CoV-2 epidemics in China
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Abstract
Background
To allow a return to a pre-COVID-19 lifestyle, virtually every country has initiated a vaccination program to mitigate severe disease burden and control transmission. However, it remains to be seen whether herd immunity will be within reach of these programs.
Methods
We developed a compartmental model of SARS-CoV-2 transmission for China, a population with low prior immunity from natural infection. Two vaccination programs were tested and model-based estimates of the immunity level in the population were provided.
Results
We found that it is unlikely to reach herd immunity for the Delta variant given the relatively low efficacy of the vaccines used in China throughout 2021 and the lack of prior natural immunity. We estimated that, assuming a vaccine efficacy of 90% against the infection, vaccine-induced herd immunity would require a coverage of 93% or higher of the Chinese population. However, even when vaccine-induced herd immunity is not reached, we estimated that vaccination programs can reduce SARS-CoV-2 infections by 50–62% in case of an all-or-nothing vaccine model and an epidemic starts to unfold on December 1, 2021.
Conclusions
Efforts should be taken to increase population’s confidence and willingness to be vaccinated and to develop highly efficacious vaccines for a wide age range.
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SciScore for 10.1101/2021.07.23.21261013: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study is prone to the limitations pertaining to modeling exercises. First, VE for children have not been estimated for the vaccines in use in China; therefore, we have assumed the same VE as in adults based on immunogenicity studies 51. Given such a lack of field evidence, we have conducted a sensitivity analysis where a lower …
SciScore for 10.1101/2021.07.23.21261013: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study is prone to the limitations pertaining to modeling exercises. First, VE for children have not been estimated for the vaccines in use in China; therefore, we have assumed the same VE as in adults based on immunogenicity studies 51. Given such a lack of field evidence, we have conducted a sensitivity analysis where a lower vaccine efficacy is assumed for children. The overall conclusions of the study do not change. Still, further data on age-specific vaccine efficacy could help refine the obtained estimates. Second, we assumed that immunity induced either from infection or vaccination lasts more than the time horizon considered in the simulations (i.e., 1 year). There are both evidence from laboratory studies and the field suggesting that the protection lasts several months 52-54. Despite these preliminary pieces of evidence, the duration of the immunity remains a research area of paramount importance and intrinsically linked to viral evolution. It is also possible that waning immunity will continue to provide protection against severe disease but only partial against infection or transmission, which affects the herd immunity threshold. Overall, the duration and quality of immunity will determine the periodicity of COVID-19 outbreaks globally 55,56. Third, in the baseline scenario, we referred to an inactivated SARS-CoV-2 vaccine (BBIBP-CorV) taken to be 73.5% efficacious against infection 17. However, several other vaccines (including CoronaVac, WBIP-CorV, Ad5 nCoV,...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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