Variant-of-concern-attributable health and health system-related outcomes: a population-level propensity-score matched cohort study

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1. 

   ScreenIT

   Jun 6, 2021

   SciScore for 10.1101/2021.06.02.21257869: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	not detected.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   13 Statistical analyses were performed using R version 3.6.3 with RStudio (R Core Team, 2020).	RStudio suggested: (RStudio, RRID:SCR_000432)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   However, our study also has limitations. The analysis is limited by the inability to control for …

   SciScore for 10.1101/2021.06.02.21257869: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	not detected.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   13 Statistical analyses were performed using R version 3.6.3 with RStudio (R Core Team, 2020).	RStudio suggested: (RStudio, RRID:SCR_000432)

   ---

   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

   ---

   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   However, our study also has limitations. The analysis is limited by the inability to control for unmeasured confounders especially in terms of missing comorbidity profiles and by right censoring of data. We were also unable to stratify by specific VOC lineage given lagging sequencing information, though the vast majority VOC cases are likely to be B.1.1.7. 11 Moreover, because data on ICU-related outcomes is likely to be underreported in the CCM dataset by ∼45% at the time of the analysis, ICU-related outcomes (i.e., ICU admission and ventilation/intubation) should be interpreted with caution. In conclusion, this study suggests that VOCs that that harbour the N501Y mutation, which confers greater infectivity, is also associated with more severe disease manifestations relative to earlier strains. Taken together, these findings suggest that compared to the previous phases of the pandemic, health systems will likely face increased demand for acute care hospital and ICU resources as VOCs predominate worldwide, especially in view of limited global vaccination coverage. Therefore, prompt vaccine roll-out particularly in regions with high incidence of VOC is warranted to reduce the global burden of COVID-19 going forward.

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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   Results from scite Reference Check: We found no unreliable references.

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   Read the original source
2. 

   Version published to 10.1101/2021.06.02.21257869v1 on medRxiv

   Jun 3, 2021