Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection
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Abstract
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SciScore for 10.1101/2021.05.27.21257944: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Eligible patients were adults aged 18 or older referred to the post-COVID-19 outpatient clinic who provided written informed consent for participation in a research registry and collection of their clinical data.
IRB: The study was approved by the institutional review board of the University of Iowa.Sex as a biological variable not detected. Randomization not detected. Blinding Qualitative CT image analysis was performed by an experienced, blinded radiologist (P.N.). Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analyses were performed using GraphPad Prism or R statistical software (http://www.r-project.org). GraphPad Prismsuggested: …SciScore for 10.1101/2021.05.27.21257944: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Eligible patients were adults aged 18 or older referred to the post-COVID-19 outpatient clinic who provided written informed consent for participation in a research registry and collection of their clinical data.
IRB: The study was approved by the institutional review board of the University of Iowa.Sex as a biological variable not detected. Randomization not detected. Blinding Qualitative CT image analysis was performed by an experienced, blinded radiologist (P.N.). Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analyses were performed using GraphPad Prism or R statistical software (http://www.r-project.org). GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)http://www.r-project.orgsuggested: (R Project for Statistical Computing, RRID:SCR_001905)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations: This is single center study, and thus the generalizability of our findings may be limited. Furthermore, we only evaluated symptomatic patients, and therefore cannot comment on the prevalence of lung function and imaging abnormalities among all COVID-19 survivors. Longitudinal assessment will be required to determine whether PASC-fSAD improves over time, or whether it leads to persist or progressive lung disease. Conclusions: Our study demonstrates that patients with PASC have a high prevalence of long-lasting air trapping by imaging, regardless of the initial severity of infection. Air trapping is often missed with spirometry but can be detected using inspiratory and expiratory CT imaging and plethysmography. Studies aimed at determining the natural history of PASC-fSAD and the biological mechanisms that underlie these findings are urgently needed in order to identify therapeutic and preventative interventions.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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