Effectiveness of BNT162b2 mRNA vaccine and ChAdOx1 adenovirus vector vaccine on mortality following COVID-19
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Abstract
We estimated risk of death in vaccinated compared to unvaccinated COVID-19 cases. Cases vaccinated with 1 dose of BNT162b2 had 44% reduced risk of death, 55% with 1 dose of ChAdOx1, and 69% with 2 doses of BNT162b2. This is on top of the protection provided against becoming a case.
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SciScore for 10.1101/2021.05.14.21257218: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, we have previously found that vaccine effects occur more rapidly with BNT162b2, so this could represent early vaccine effects.(2) A further limitation is that some of the deaths within 28 days of a positive test may be unrelated to COVID and …
SciScore for 10.1101/2021.05.14.21257218: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, we have previously found that vaccine effects occur more rapidly with BNT162b2, so this could represent early vaccine effects.(2) A further limitation is that some of the deaths within 28 days of a positive test may be unrelated to COVID and therefore not preventable by vaccination. All of the individuals included in this analysis had reported symptoms of COVID-19, therefore the proportion of deaths unrelated to COVID is likely to be small, however, this could cause us to underestimate the effects on mortality. In conclusion, we find strong evidence that both vaccines offer high levels of protection against mortality after a single dose which supports prioritising the first dose in at risk groups in the context of high disease incidence and vaccine supply or delivery constraints. Nevertheless, a second dose of BNT162b2 offers yet further protection against mortality, highlighting the importance of completing the course. We are not yet able to estimate two dose effects with ChAdOx1 due to the later rollout of this vaccine.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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