Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study
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SciScore for 10.1101/2021.03.11.21253364: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A significant limitation of the data available for our work is that determination of SGTF status, as a proxy for VOC B.1.1.7, was only possible in just over 50% of patients with a community COVID-19 RT-PCR positive test. To …
SciScore for 10.1101/2021.03.11.21253364: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A significant limitation of the data available for our work is that determination of SGTF status, as a proxy for VOC B.1.1.7, was only possible in just over 50% of patients with a community COVID-19 RT-PCR positive test. To minimise the risks of changing eligibility over time, we restricted our analysis to an eleven-week period where VOC B.1.1.7 had become significant. We used established measures, including critical care mortality and measures of critical care severity, including duration of critical care stay and receipt of basic and advanced organ support. Our data are very timely, being reported during the third pandemic wave in England. However, due to the data available, we were able to estimate risk of critical care admission and mortality only among individuals tested in the community, who are generally healthier and younger than those tested in hospitals. More robust results will be possible as more testing data becomes available. As with all observational studies, our study remains subject to unmeasured confounding. Our study demonstrates increased risk of COVID-19 28-day mortality and risk of critical care admission for patients who test positive for VOC B.1.1.7. Combined with evidence of increased infectivity, our findings emphasise the importance of measures to control exposure to and infection with COVD-19.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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