Previous SARS-CoV-2 infection increases B.1.1.7 cross-neutralization by vaccinated individuals

  1. Benjamin Trinité
  2. Edwards Pradenas
  3. Silvia Marfil
  4. Carla Rovirosa
  5. Víctor Urrea
  6. Ferran Tarrés-Freixas
  7. Raquel Ortiz
  8. Júlia Vergara-Alert
  9. Joaquim Segalés
  10. Victor Guallar
  11. Rosalba Lepore
  12. Nuria Izquierdo-Useros
  13. Glòria Trujillo
  14. Jaume Trapé
  15. Carolina González-Fernández
  16. Antonia Flor
  17. Rafel Pérez-Vidal
  18. Anna Chamorro
  19. Roger Paredes
  20. Ignacio Blanco
  21. Eulalia Grau
  22. Marta Massanella
  23. Jorge Carrillo
  24. Bonaventura Clotet
  25. Julià Blanco

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Abstract

To assess the potential impact of predominant circulating SARS-CoV-2 variants on neutralizing activity of infected and/or vaccinated individuals, we analyzed neutralization of pseudoviruses expressing the spike of the original Wuhan strain, the D614G and B.1.1.7 variants. Our data show that parameters of natural infection (time from infection and infecting variant) determined cross-neutralization. Importantly, upon vaccination, previously infected individuals developed equivalent B.1.1.7 and Wuhan neutralizing responses. In contrast, uninfected vaccinees showed reduced neutralization against B.1.1.7.

Funding

This study was funded by Grifols, the Departament de Salut of the Generalitat de Catalunya , the Spanish Health Institute Carlos III, CERCA Programme/ Generalitat de Catalunya , and the crowdfunding initiatives #joemcorono, BonPreu/Esclat and Correos.

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  1. ScreenIT

    SciScore for 10.1101/2021.03.05.433800: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

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  2. Version published to 10.1101/2021.03.05.433800 on bioRxiv