Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans
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Abstract
The COVID-19 pandemic caused by SARS-CoV-2 started in fall 2019. A range of different mammalian species, including farmed mink, have been confirmed as susceptible to infection with this virus. We report here the spillover of mink-adapted SARS-CoV-2 from farmed mink to humans after extensive adaptation that lasted at least 3 months. We found the presence of four mutations in the S gene (that gave rise to variant: G75V, M177T, Y453F and C1247F) and others in an isolate obtained from SARS-CoV-2 positive patient.
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SciScore for 10.1101/2021.03.05.433713: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IACUC: This study was approved by the Independent Bioethical Committee for Scientific Research at the Medical University of Gdansk, Gdansk, Poland (Statement no. NKBBN/183/2020). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources ARTICv3 amplicon generation followed by Oxford Nanopore Technology MinION run was performed (Quick 2020). MinIONsuggested: (MinION, RRID:SCR_017985)ARCTIC pipeline software were used to generate SARS-CoV-2 genome. ARCTICsuggested: (ARCTIC, RRID:SCR_005989)Results from OddPub: We did not detect open data. We also did …
SciScore for 10.1101/2021.03.05.433713: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IACUC: This study was approved by the Independent Bioethical Committee for Scientific Research at the Medical University of Gdansk, Gdansk, Poland (Statement no. NKBBN/183/2020). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources ARTICv3 amplicon generation followed by Oxford Nanopore Technology MinION run was performed (Quick 2020). MinIONsuggested: (MinION, RRID:SCR_017985)ARCTIC pipeline software were used to generate SARS-CoV-2 genome. ARCTICsuggested: (ARCTIC, RRID:SCR_005989)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
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