Seroepidemiology of SARS-CoV-2 infections in an urban Nicaraguan population
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Abstract
In a Nicaraguan population-based cohort, SARS-CoV-2 seroprevalence was 34%, with higher prevalence in children compared to adults. Having a seropositive household member was associated with a two-fold probability of individual seropositivity, suggesting a role for household transmission. Co-morbidities and preventive behaviors were not associated with SARS-CoV-2 seroprevalence.
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SciScore for 10.1101/2021.02.25.21252447: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Institutional Review Boards of the National Autonomous University of Nicaragua, León (UNAN-León, acta No. 170, 2020) and the University of North Carolina at Chapel Hill (Study #: 20-2126).
Consent: All adult participants provided informed consent, and parental permission was required for children’s participation in the study.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources 5 We used an in-house enzyme-linked immunosorbent (ELISA) assay to measure antibodies (IgG, IgA, and IgM) to the receptor binding domain (RBD) of … SciScore for 10.1101/2021.02.25.21252447: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Institutional Review Boards of the National Autonomous University of Nicaragua, León (UNAN-León, acta No. 170, 2020) and the University of North Carolina at Chapel Hill (Study #: 20-2126).
Consent: All adult participants provided informed consent, and parental permission was required for children’s participation in the study.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources 5 We used an in-house enzyme-linked immunosorbent (ELISA) assay to measure antibodies (IgG, IgA, and IgM) to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, which we have previously shown to be highly sensitive and specific for detecting antibodies for at least six months among individuals experiencing symptomatic infection. IgMsuggested: NoneSARS-CoV-2 spike protein,suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
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