Critical COVID-19 represents an endothelial disease with high similarity to kidney disease on the molecular level

  1. Justyna Siwy
  2. Ralph Wendt
  3. Amaya Albalat
  4. Tianlin He
  5. Harald Mischak
  6. William Mullen
  7. Agnieszka Latosińska
  8. Christoph Lübbert
  9. Sven Kalbitz
  10. Alexandre Mebazaa
  11. Björn Peters
  12. Bernd Stegmayr
  13. Goce Spasovski
  14. Thorsten Wiech
  15. Jan A. Staessen
  16. Johannes Wolf
  17. Joachim Beige

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Abstract

In patients with critical or mild COVID19 (WHO stages 6-8 [n=53] and stages 1-3 [n=66]), 593 urinary peptides significantly affected by disease severity were identified, reflecting the molecular pathophysiology associated with the course of the infection. The peptide profiles were similar compared with those observed in kidney disease, a prototype of target organ damage with major microvascular involvement, thereby confirming the observation that endothelial damage is a hallmark of COVID19. The clinical corollary is that COVID19 is an indication for anti-oxidative, anti-inflammatory and immunosuppressive treatment modalities protecting the endothelial lining.

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  1. ScreenIT

    SciScore for 10.1101/2021.02.22.21252207: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: This study was approved by the local ethics committee (Saxon Chamber of Physicians, registry number #EK-BR-88/20-1), with a waiver of informed consent and by the Institutional Review Boards of all participating centres.
    Consent: This study was approved by the local ethics committee (Saxon Chamber of Physicians, registry number #EK-BR-88/20-1), with a waiver of informed consent and by the Institutional Review Boards of all participating centres.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Immunophenotyping of lymphocytes was performed by an 8-color T (CD3+), and B (CD19+) cytometry with monoclonal antibodies including anti-CD99 (BD Biosciences, supplementary figure 1) on BD FACSLyric™ flow cytometer (BD Biosciences).
    CD3+
    suggested: None
    anti-CD99
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1101/2021.02.22.21252207v1 on medRxiv