Persisting adaptive immunity to SARS-CoV-2 in Lower Austria

  1. Dennis Ladage
  2. Oliver Harzer
  3. Peter Engel
  4. Hannes Winkler
  5. Ralf J. Braun

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Abstract

The prevalence and persistence of adaptive immunity responses following a SARS-CoV-2 infection provides insights into potential population immunity. Adaptive immune responses comprise of antibody-based responses as well as T cell responses mainly addressing viruses and virus-infected human cells, respectively. A comprehensive analysis of both types of adaptive immunity is essential to follow population-based SARS-CoV-2-specific immunity. In this study, we assessed SARS-CoV-2-specific immunoglobulin A (IgA) levels, SARS-CoV-2-specific immunoglobulin G (IgG) levels, and SARS-CoV-2-specific T cell activities in patients who recovered from a COVID-19 infection in spring and autumn 2020. Here we observed a robust and stable SARS-CoV-2-specific adaptive immune response in both groups with persisting IgA and IgG levels as well as stable T cell activity. Moreover, there was a positive correlation of a lasting immune response with the severity of disease. Our data give evidence for a persisting adaptive immune memory, which suggest a continuing immunity for more than six months post infection.

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  1. ScreenIT

    SciScore for 10.1101/2021.02.18.21251551: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

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  2. Version published to 10.1101/2021.02.18.21251551v1 on medRxiv