Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity
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Abstract
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SciScore for 10.1101/2020.12.15.20248279: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources An IVW leave-one-out analysis, implemented in the MendelianRandomization R package was also performed to determine whether any outliers could bias the overall causal estimate. MendelianRandomizationsuggested: NoneResults from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study also has some limitations, such as the modest variance explained by the IPF genetic …
SciScore for 10.1101/2020.12.15.20248279: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources An IVW leave-one-out analysis, implemented in the MendelianRandomization R package was also performed to determine whether any outliers could bias the overall causal estimate. MendelianRandomizationsuggested: NoneResults from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study also has some limitations, such as the modest variance explained by the IPF genetic instruments, although within the range typical of complex traits. Nevertheless, the use of weak genetic instruments could only create biases estimates towards the null. Increased sample sizes, both from the IPF or COVID-19 GWAS could also have narrowed our confidence intervals around the true estimates, although we used the largest sample sizes for IPF and COVID-19 to date. Furthermore, MR-Egger results were not as compelling as the IVW or weighted median, suggesting that confounding factors could have biased the effect estimates. However, MR-Egger is usually considered as a sensitivity method which can also be biased in certain situations39. Moreover, the COVID-19 control groups, drawn from the general population, were of unknown virus exposure status, which might have further biased our causal estimates towards the null. In summary, our study provides genetic evidence that supports shared causal genetic etiology between IPF and COVID-19 severity that could inform the design of future preventive and therapeutic strategies to treat COVID-19.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
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