Extended in vitro inactivation of SARS-CoV-2 by titanium dioxide surface coating

Article activity feed

1. 

   ScreenIT

   Dec 9, 2020

   SciScore for 10.1101/2020.12.08.415018: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Institutional Review Board Statement	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Sex as a biological variable	not detected.
   Cell Line Authentication	not detected.

   Table 2: Resources

   Antibodies
   Sentences	Resources
   24 h post-infection cells were fixed, stained for nucleocapsid protein (anti-Nucleocapsid antibody, MA5-36086, ThermoFisher) and %infection determined by flow cytometry.	anti-Nucleocapsid suggested: None
   Experimental Models: Cell Lines
   Sentences	Resources
   Cell lines: 293T and Vero E6 cells were cultured in DMEM complete (DMEM supplemented with 100 U/ml penicillin, 0.1 mg/ml streptomycin, and 10% fetal calf serum).	293T suggested: None
   The titre of the stock was …

   SciScore for 10.1101/2020.12.08.415018: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Institutional Review Board Statement	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Sex as a biological variable	not detected.
   Cell Line Authentication	not detected.

   Table 2: Resources

   Antibodies
   Sentences	Resources
   24 h post-infection cells were fixed, stained for nucleocapsid protein (anti-Nucleocapsid antibody, MA5-36086, ThermoFisher) and %infection determined by flow cytometry.	anti-Nucleocapsid suggested: None
   Experimental Models: Cell Lines
   Sentences	Resources
   Cell lines: 293T and Vero E6 cells were cultured in DMEM complete (DMEM supplemented with 100 U/ml penicillin, 0.1 mg/ml streptomycin, and 10% fetal calf serum).	293T suggested: None
   The titre of the stock was determined by adding tenfold serial dilutions of virus onto Vero E6 cells.	Vero E6 suggested: RRID:CVCL_XD71)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   Conversely, a limitation is that if a sudden very large contamination event occurred, particularly one that severely diminished the light reaching the photocatalyst, it might take impracticably long for the contamination to be eliminated. Hence, in that case rough cleaning, even washing with water, should be used to remove the gross contamination. The efficacy of the TiO2 coating under typical hospital lighting makes it a promising candidate for enhancing the protection afforded by facemasks and other PPE, and well as surfaces likely to be contaminated and hence acting as reservoirs for transmitting infection if left untreated.

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • No funding statement was detected.
   • No protocol registration statement was detected.

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   Read the original source
2. 

   Version published to 10.1101/2020.12.08.415018v1 on bioRxiv

   Dec 8, 2020