Association of Antihypertensive Agents with the Risk of In-Hospital Death in Patients with Covid-19
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SciScore for 10.1101/2020.11.23.20237362: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The Institutional Review Board of the AP-HP Health Data Warehouse approved this study on April 7th, 2020 (CSE-20-18_COVID19). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Antihypertensive agent exposure have been identified in EHRs at admission of the hospital stay for Covid-19 and within the six previous months, using both specific Anatomical Therapeutic Chemical classification (ATC) codes and deep learning algorithm on clinical narratives as previously described (Suppl Table S2). ATCsuggested: NoneResults from OddPub: We did not …
SciScore for 10.1101/2020.11.23.20237362: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The Institutional Review Board of the AP-HP Health Data Warehouse approved this study on April 7th, 2020 (CSE-20-18_COVID19). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Antihypertensive agent exposure have been identified in EHRs at admission of the hospital stay for Covid-19 and within the six previous months, using both specific Anatomical Therapeutic Chemical classification (ATC) codes and deep learning algorithm on clinical narratives as previously described (Suppl Table S2). ATCsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has some limitations. First, in this retrospective observational design on hospitalized Covid-19 patients, hypertension or antihypertensive exposure could have affected the chance of hospitalization, which may limit the generalizability of our results. Second, although analyses were adjusted on major comorbidities, some unmeasured or unknown confounders may have not been ruled out, including indication bias. Finally, ascertainment of medication use from EHRs may not capture all drug prescriptions and not reflect actual drug exposure. However, considering antihypertensive agents are chronic treatments, we consider exposure to these drugs up to six months prior to hospitalization for Covid-19.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
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