Virucidal efficacy of different formulations for hand and surface disinfection targeting SARS CoV-2

  1. Katrin Steinhauer
  2. Toni Luise Meister
  3. Daniel Todt
  4. Adalbert Krawczyk
  5. Lars Paßvogel
  6. Britta Becker
  7. Dajana Paulmann
  8. Birte Bischoff
  9. Maren Eggers
  10. Stephanie Pfaender
  11. Florian H H Brill
  12. Eike Steinmann

Reviewed by

Read the full article See related articles

Discuss this preprint

Start a discussion What are Sciety discussions?

Listed in

Log in to save this article

Abstract

In the ongoing SARS CoV-2 pandemic effective measures are needed, and guidance based on the methodological framework of the European committee for standardization (CEN) can help to choose effective disinfectants on an immediate basis. This study demonstrates that two commercially available formulations for surface disinfection and one formulation for hand disinfection claiming “virucidal activity against enveloped viruses” are effectively inactivating SARS-CoV-2. This study emphasizes that chemical disinfectants claiming “virucidal activity against enveloped viruses” are an effective choice to target enveloped SARS-CoV-2 as a preventive measure.

Article activity feed

  1. ScreenIT

    SciScore for 10.1101/2020.11.08.373738: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.
    Cell Line Authenticationnot detected.

    Table 2: Resources

    Experimental Models: Cell Lines
    SentencesResources
    For Modified vaccinia virus Ankara (provided from the Institute of Animal Hygiene and Veterinary Public Health of the University Leipzig), BHK-21 cells were used (provided by Friedrich Löffler institute); for vaccinia virus Elstree (kindly provided by Prof. Sauerbrei, University of Jena, Jena,
    BHK-21
    suggested: ATCC Cat# CRL-6282, RRID:CVCL_1914)
    SARS-CoV-2 (strain Essen) was propagated on Vero E6 cells as previously described [8].
    Vero E6
    suggested: RRID:CVCL_XD71)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1101/2020.11.08.373738 on bioRxiv