Dietary Nicotianamine as a Factor in International Variations of Mortality from Covid-19

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Abstract

Nicotianamine is a compound found only in plants that strongly binds to and potently inhibits at nanomolar concentrations the angiotensin converting enzyme 2 (ACE2) which is the human cell receptor for the coronavirus SARS-CoV-2. Because of its ACE2 binding activity it can potentially reduce mortality from Covid-19. This report explores the inverse association of dietary nicotianamine intake with mortality from Covid-19 from numerous countries. The data support a probable dramatic effect of nicotianamine in reducing coronavirus mortality. The best-case scenario of consuming a diet high in nicotianamine is a 100-fold reduction in Covid-19 mortality. Worst case is that one consumes a more healthful diet that is less expensive and more environmentally friendly.

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  1. SciScore for 10.1101/2020.10.15.20213470: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

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