Transmission of SARS-CoV-2 from Children and Adolescents

This article has been Reviewed by the following groups

Read the full article

Discuss this preprint

Start a discussion What are Sciety discussions?

Abstract

A better understanding of SARS-CoV-2 transmission from children and adolescents is crucial for informing public health mitigation strategies. We conducted a retrospective cohort study among household contacts of primary cases defined as children and adolescents aged 7⍰19 years with laboratory evidence of SARS-CoV-2 infection acquired during an overnight camp outbreak. Among household contacts, we defined secondary cases using the Council of State and Territorial Epidemiologists definition. Among 526 household contacts of 224 primary cases, 48 secondary cases were identified, corresponding to a secondary attack rate of 9% (95% confidence interval [CI], 7%–12%). Our findings show that children and adolescents can transmit SARS-CoV-2 to adult contacts and other children in a household setting.

Article activity feed

  1. SciScore for 10.1101/2020.10.10.20210492: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    However, our findings are subject to at least three limitations. First, this was a retrospective observational study with selection and recall bias. Second, the participating household contacts were predominantly non-Hispanic White with a college degree and therefore not representative of the general population. Third, differential misclassification leading to SAR underestimation might have occurred as not all household contacts were tested for SARS-CoV-2, test results were self-reported, and many contacts were tested only once and could have been tested too early. Alternatively, SAR could have been overestimated due to inability to distinguish household or community SARS-CoV-2 infection source, and between secondary and tertiary household transmission. In this investigation, school-aged children and adolescents with COVID-19 transmitted SARS-CoV-2 to other children and adults in the household setting, with 10% of secondary adult cases requiring hospitalization. These findings highlight the importance of implementing effective public health guidelines to prevent SARS-CoV-2 transmission in all settings, including settings with children. Children and adolescents should remain at home, ≥6 feet apart from contacts, and have a separate sleeping space and bathroom following a known COVID-19 exposure or diagnosis. In communities with active SARS-CoV-2 spread, and particularly in congregate settings, children and adolescents should wear masks if safe to do so and maintain at least si...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.