Possible transmission flow of SARS-CoV-2 based on ACE2 features

  1. Sk. Sarif Hassan
  2. Shinjini Ghosh
  3. Diksha Attrish
  4. Pabitra Pal Choudhury
  5. Vladimir N. Uversky
  6. Bruce D. Uhal
  7. Kenneth Lundstrom
  8. Nima Rezaei
  9. Alaa A. A. Aljabali
  10. Murat Seyran
  11. Damiano Pizzol
  12. Parise Adadi
  13. Antonio Soares
  14. Tarek Mohamed Abd El-Aziz
  15. Ramesh Kandimalla
  16. Murtaza Tambuwala
  17. Gajendra Kumar Azad
  18. Samendra P. Sherchan
  19. Wagner Baetas-da-Cruz
  20. Kazuo Takayama
  21. Ángel Serrano-Aroca
  22. Gaurav Chauhan
  23. Giorgio Palu
  24. Adam M. Brufsky

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Abstract

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.

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    SciScore for 10.1101/2020.10.08.332452: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

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    Table 2: Resources

    Software and Algorithms
    SentencesResources
    (Large flying fox), Rattus norvegicus (Brown rat), Felis catus (Domestic cat), and Gallus gallus (Red jungle fowl) were derived from the NCBI database [23].
    NCBI
    suggested: (NCBI, RRID:SCR_006472)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • No funding statement was detected.
    • No protocol registration statement was detected.

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  2. Version published to 10.1101/2020.10.08.332452 on bioRxiv