Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19

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Abstract

No abstract available

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  1. SciScore for 10.1101/2020.10.05.20207118: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: Thank you for sharing your data.


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our study had several limitations. Firstly, our analyses were limited by the number of genetic variants that overlapped between the COVID-19 HG meta-analysis and the datasets that were used for this study. Thus, we could not test some genes that may be of importance. Secondly, replication of our result in an independent dataset was not possible due to the lack of COVID-19 GWAS data available at the present time; therefore first-time associations identified by our analyses should be considered with caution. Lastly, the lung and blood -omics data used reflect the transcriptomic and proteomic profile under normal conditions, however it is likely that that these associations may change under stimulation by viral infection or acute inflammation.

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • No funding statement was detected.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.