Dynamic Modeling of Reported COVID-19 Cases and Deaths with Continuously Varying Case Fatality and Transmission Rate Functions

  1. Mingdong Lyu
  2. Randolph Hall

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Abstract

In this paper, we propose an enhanced SEIRD (Susceptible-Exposed-Infectious-Recovered-Death) model with time varying case fatality and transmission rates for confirmed cases and deaths from COVID-19. We show that when case fatalities and transmission rates are represented by simple Sigmoid functions, historical cases and fatalities can be fit with a relative-root-mean-squared-error accuracy on the order of 2% for most American states over the period from initial cases to July 28 (2020). We find that the model is most accurate for states that so far had not shown signs of multiple waves of the disease (such as New York), and least accurate for states where transmission rates increased after initially declining (such as Hawaii). For such states, we propose an alternate multi-phase model. Both the base model and multi-phase model provide a way to explain historical reported cases and deaths with a small set of parameters, which in the future can enable analyses of uncertainty and variations in disease progression across regions.

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    SciScore for 10.1101/2020.09.25.20201905: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

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  2. Version published to 10.1101/2020.09.25.20201905v1 on medRxiv