Post-COVID-19 functional status

  1. Aliae AR Mohamed Hussein
  2. Mahmoud Saad
  3. Hossam E Zayan
  4. Mustafa Abdelsayed
  5. Mohamed Moustafa
  6. Abdel Rahman Ezzat
  7. Radwa Helmy
  8. Howaida Abd-Elaal
  9. Karim Aly
  10. Shaimaa Abdelrheem
  11. Islam Sayed

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Abstract

Recently, a new “Post-COVID-19 Functional Status (PCFS) scale” is recommended in the current COVID-19 pandemic. It is proposed that it could be used to display direct retrieval and the functional sequelae of COVID-19.

AIM OF THE STUDY:

The aim of the study was to assess the PCFS and to evaluate if age, gender, smoking, hospitalization, and comorbidities have any effect on functional limitations in recovered COVID-19 patients.

METHODS:

A total of 444 registered confirmed COVID-19 patients were included. They were interviewed in our follow-up clinics and filled an Arabic translated PCFS scale as well as their demographic and clinical data.

RESULTS:

Eighty percent of COVID-19 recovered cases have diverse degrees of functional restrictions ranging from negligible (63.1%), slight (14.4%), moderate (2%), to severe (0.5%) based on PCFS. Furthermore, there was a substantial variance between the score of PCFS with age ( P = 0.003), gender ( P = 0.014), the duration since the onset of the symptoms of COVID-19 ( P < 0.001), need for oxygen supplementation ( P < 0.001), need for intensive care unit (ICU) admittance ( P = 0.003), previous periodic influenza vaccination ( P < 0.001), smoking status ( P < 0.001), and finally, the presence of any comorbid disorder ( P < 0.001).

CONCLUSIONS:

Most of the COVID-19 recovered cases have diverse degrees of functional restrictions ranging from negligible to severe based on PCFS. These restrictions were affected by age, gender, periodic influenza vaccination, smoking, duration since symptoms onset, need for oxygen or ICU admittance, and finally the presence of coexisting comorbidity.

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  1. Version published to 10.4103/atm.atm_606_20
  2. ScreenIT

    SciScore for 10.1101/2020.08.26.20182618: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Limitations of the study: first, the lack of data of functional status before COVID-19 infection; second, the history of the symptoms both at the onset of COVID-19 and after recovery is not included; third, the pharmacologic therapy given to the patients was not mentioned (however all patients received the standard protocol of Ministry of health and population in Egypt but it was changed several times according to international recommendations), lastly, random selection bias may be present and an inability for personal face-to-face interview in some cases. Conclusions: Most of COVID-19 recovered cases have different degrees of functional limitations ranging from negligible to severe based on PCFS. These limitations were affected by age, gender, periodic influenza vaccination, smoking status, duration since symptoms onset, need for oxygen therapy or ICU admittance, and lastly the presence of coexisting comorbidity. It is recommended that Post COVID-19 monitoring programs should be implemented in specific clinical settings or as an out-patients program to follow the functional status of patients in 1, 3, 6 months visits to support the complete care for cases recovered from COVID-19. Furthermore, extended monitoring using simple scales as PCFS is necessary to determine whether these functional deficits after COVID-19 recovery persist or not. Further studies are required to explain the underlying cause of post COVID-19 functional limitation.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    NCT04479293RecruitingPost COVID-19 Functional Status in Egypt

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.08.26.20182618v1 on medRxiv