Impact of Duration of Cessation of Mass BCG Vaccination Programs on COVID-19 Mortality

  1. Tareef Fadhil Raham

Reviewed by

Read the full article See related articles

Listed in

Log in to save this article

Abstract

Back ground

BCG have heterogeneous immunity to certain pathogens other than Mycobacterium tuberculosis effect. At early times during COVID-19 pandemic heterogeneous immunity towards (SARS-CoV-2), was hypothesized and statistical correlation between of BCG vaccination practices and COVID-19 mortality variances among countries was statistically proved. These studies were criticized because of low evidence of such studies and possible confounding factors. For that reason, this study was designed to look for impact of duration of cessation of BCG programs on COVID-19 mortality looking for the hypotheses by different design and looking forward to support previous studies.

Methods

Total number of studied group is 14 countries which had stopped BCG vaccination programs.

Through applying stem-leaf plot for exploring data screening behavior concerning COVID-19Mortality for obsolescence duration of cessation of mass BCG vaccination programs, as well as (nonlinear regression of compound model) for predicted shape behavior for that group.

Results

Slope value shows highly significant effectiveness of obsolescence of cessation of mass BCG vaccination programs on COVID-19 mortality at P -value <0.000. Obsolescence of duration of cessation of mass BCG vaccination programs has strong negative association with COVID-19 mortality in countries which stopped BCG vaccination programs.

Conclusiaon

The longer the cessation duration of BCG programs, the higher the COVID-19mortality is, and vice versa.

Article activity feed

  1. ScreenIT

    SciScore for 10.1101/2020.08.20.20178889: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Information on past BCG vaccination and cessation dates were collected from countries by data abstracted from published papers, reports, and available government policy documents retrieved through literature searches on PubMed and via the World Wide Web furthermore, we used immunization data available from the WHO-UNICEF estimates of BCG coverage site: https://apps.who.int/immunization_monitoring/globalsummary/timeseries/tswucoveragebcg.html and WHO UNICEF review of national immunization coverage, 1980-2018 and immunization surveillance, assesment and monitoring data at site: https://www.who.int/immunization/monitoring_surveillance/data/afg.pdf It was not appropriate or possible to involve patients or the public in this work.
    PubMed
    suggested: (PubMed, RRID:SCR_004846)
    All statistical operations were performed through using the ready-made statistical package SPSS, version 22.
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1101/2020.08.20.20178889v2 on medRxiv
  3. Version published to 10.1101/2020.08.20.20178889v1 on medRxiv