Covid-19 and dysregulated cerebral perfusion: observations with multimodal MRI

  1. Marie-Cécile Henry-Feugeas
  2. Augustin Gaudemer
  3. Xavier Lescure
  4. Antoine Dossier
  5. Romain Sonneville
  6. Carsten Ehmer
  7. Christophe Choquet
  8. Theresa Israel
  9. Agathe Raynaud Simon
  10. Raphael Borie
  11. Pierre Amarenco
  12. Antoine Khalil

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Abstract

The pathogenesis of encephalopathy-associated Covid-19 is still unclear. Multimodal brain MRI in 25 Covid-19 patients with neurological symptoms revealed angiographic and brain perfusion changes suggesting an under-recognized dysregulated brain perfusion not identified by morphological neuroimaging alone. Endothelial dysfunction, a key pathomechanism of dysregulated brain perfusion, may contribute to central-nervous-system disturbances in Covid-19.

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  1. ScreenIT

    SciScore for 10.1101/2020.07.12.20100941: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Institutional review board was approved (CRM-2005-086) and written informed consent waived.
    Consent: Institutional review board was approved (CRM-2005-086) and written informed consent waived.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on page 15. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

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  2. Version published to 10.1101/2020.07.12.20100941v1 on medRxiv