SARS-CoV-2 seroprevalence in the municipality of São Paulo, Brazil, ten weeks after the first reported case

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Abstract

A population-based household survey was performed to estimate the prevalence of IgM and IgG to SARS-CoV-2 in residents of six districts in São Paulo City, Brazil. Serum samples collected from 299 randomly-selected adults and 218 cohabitants (N=517) were tested by chemiluminescence immunoassay ten weeks after the first reported case. Weighted overall seroprevalence was 4.7% (95% CI 3.0-6.6%). The low seroprevalence suggests that most of this population could still be infected. Serial serosurveys were initiated aiming to monitor the progress of the ongoing pandemic throughout the entire city. This may help inform public health authority decisions regarding prevention and control strategies.

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  1. SciScore for 10.1101/2020.06.29.20142331: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: After obtaining informed consent from the participant, the team applied a structured questionnaire to gather information on sociodemographic characteristics and occurrence of COVID-19-related symptoms in the previous two weeks.
    IACUC: The study was approved by the Fleury Institutional Ethical Committee (CAAE 31032620.0.0000.5474).
    RandomizationTo allow for non-contact and refusals, 1049 households were randomly selected and surveyed.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    The recombinant antigens containing the nucleoprotein and a peptide from the spike …