Assessment of Small Pulmonary Blood Vessels in COVID-19 Patients Using HRCT
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SciScore for 10.1101/2020.05.22.20108084: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The study has several limitations. All data was collected in the course of clinical practice during a pandemic, and was retrospective, with the result that acquisition protocols varied between centers. The characteristics of the patient were not always available, such that age, gender, and a height could not be well controlled for. …
SciScore for 10.1101/2020.05.22.20108084: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The study has several limitations. All data was collected in the course of clinical practice during a pandemic, and was retrospective, with the result that acquisition protocols varied between centers. The characteristics of the patient were not always available, such that age, gender, and a height could not be well controlled for. Normalization of BVX by total pulmonary blood volume mitigates this somewhat, as previous samplings have shown these measures to vary little across healthy populations. As noted, areas of opacification confound these algorithms. In most past studies of imaging of pulmonary blood volumes, these opacities have been grounds for excluding scans from analysis. This was neither possible nor desirable in this context given the ubiquity of these findings and their hypothesized role in the pathogenesis of COVID-19 [11-13]. BVX is normalized for total segmented blood volume, which limits the magnitude of error introduced. Notable is the presence of lobes with minimal opacity but markedly reduced BV5 compared to healthy subjects. In combination with the small effect sizes observed in the mixed effect model (Figure 5), this suggests that the detected opacities likely introduce modest error, specifically loss of BV5 and gain of BV10, but are not the singular or even primary driver of these anomalies. We speculate that observed anomalies in vascular volumes are a result of the pathogenic process of the SARS-CoV2 virus itself and possibly the resulting immune res...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT00608764 Active, not recruiting Examining the Genetic Factors That May Cause Chronic Obstruc… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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