Elevated expression of ACE2 in tumor-adjacent normal tissues of cancer patients
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Abstract
The rapidly developing COVID-19 pandemic has raised a concern that cancer patients may have increased susceptibility to SARS-CoV-2 infection. This discussion has mostly focused on therapy-induced immune suppression. Here, we examined the expression patterns of ACE2 , the receptor through which SARX-CoV2 enters human cells, and found that ACE2 mRNA levels are elevated in tumor-adjacent normal tissues of cancer patients, including in normal-adjacent lung tissues of lung cancer patients. These observations raise the possibility that the elevated COVID-19 risk of cancer patients may not be limited to those undergoing immune-suppressing treatment.
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SciScore for 10.1101/2020.04.25.061200: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources The normalized expression of ACE2 is either presented as is (Supplementary Fig. 1) or further normalized by subtracting the normalized expression of GAPDH from the normalized expression of ACE2 (Fig. 1). mRNA expression data of lung tissues were obtained from the Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/) using the following accession numbers: GSE14334, GSE14938, GSE5364, GSE19804, GSE32863 and GSE75037. Gene Expression Omnibussuggested: (Gene Expression Omnibus …SciScore for 10.1101/2020.04.25.061200: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources The normalized expression of ACE2 is either presented as is (Supplementary Fig. 1) or further normalized by subtracting the normalized expression of GAPDH from the normalized expression of ACE2 (Fig. 1). mRNA expression data of lung tissues were obtained from the Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/) using the following accession numbers: GSE14334, GSE14938, GSE5364, GSE19804, GSE32863 and GSE75037. Gene Expression Omnibussuggested: (Gene Expression Omnibus (GEO, RRID:SCR_005012)Statistical analysis: Statistical analyses were performed using PRISM GraphPad 8.4.1. PRISMsuggested: (PRISM, RRID:SCR_005375)GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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