Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection

  1. Anuradha Lala
  2. Kipp W. Johnson
  3. James L. Januzzi
  4. Adam J. Russak
  5. Ishan Paranjpe
  6. Felix Richter
  7. Shan Zhao
  8. Sulaiman Somani
  9. Tielman Van Vleck
  10. Akhil Vaid
  11. Fayzan Chaudhry
  12. Jessica K. De Freitas
  13. Zahi A. Fayad
  14. Sean P. Pinney
  15. Matthew Levin
  16. Alexander Charney
  17. Emilia Bagiella
  18. Jagat Narula
  19. Benjamin S. Glicksberg
  20. Girish Nadkarni
  21. Donna M. Mancini
  22. Valentin Fuster

Reviewed by

Read the full article

Listed in

Log in to save this article

Abstract

No abstract available

Article activity feed

  1. Version published to 10.1016/j.jacc.2020.06.007
  2. ScreenIT

    SciScore for 10.1101/2020.04.20.20072702: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: The Mount Sinai Institutional Review Board approved this research under a regulatory protocol allowing for analysis of patient-level COVID-19 data.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Troponin I concentrations were assessed via the Abbott Architect method (Abbott, Abbott Park, Illinois) wherein the 99th percentile for a normal population is 0.028 ng/mL.
    Abbott
    suggested: (Abbott, RRID:SCR_010477)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Limitations: There are some notable limitations of the present analysis. First, there are limitations inherent to the use of EHR for patient level data in such a large sample size not explicitly verified by manual chart review. Despite these limitations, the use of EHR enabled timely analysis and rapid dissemination of crucial information in a large patient cohort at the epicenter of the pandemic. Second, some patients included had not completed their hospital course at the time of data freeze. We accounted for this by conducting a secondary, complementary survival analysis where hospital discharge was treated as a competing risk as outlined in the Methods section. Results from our competing risks analysis were not meaningfully different from a standard survival analysis where discharged patients were simply considered to be right-censored. Lastly our outcomes analyses were focused upon troponin measurements made at hospital admission and less upon serial troponin measurements obtained over the course of each patient’s hospital stay, although we provide plots demonstrating trends in serial troponin measurements.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.04.20.20072702v2 on medRxiv
  4. Version published to 10.1101/2020.04.20.20072702v1 on medRxiv