Clonal chromosomal mosaicism and loss of chromosome Y in men are risk factors for SARS-CoV-2 vulnerability in the elderly

Article activity feed

1. 

   Version published to 10.1101/2020.04.19.20071357v2 on medRxiv

   Feb 18, 2022
2. 

   ScreenIT

   Jun 6, 2020

   SciScore for 10.1101/2020.04.19.20071357: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   NIH rigor criteria are not applicable to paper type.

   Table 2: Resources

   Experimental Models: Cell Lines
   Sentences	Resources
   One corresponds to primary human lung epithelium (NHBE) and the other to transformed lung alveolar cells (A549).	A549 suggested: NCI-DTP Cat# A549, RRID:CVCL_0023)
   Software and Algorithms
   Sentences	Resources
   The expression dataset is publicly available at GEO (Gene Expression Omnibus) under the accession number GSE48348.18 In this dataset, a total of 11 individuals with LOY were identified.	Gene Expression Omnibus suggested: (Gene Expression Omnibus (GEO, RRID:SCR_005012)
   Array quality was assessed using arrayQualityMetrics Bioconductor package.	arrayQualityMetrics suggested: …

   SciScore for 10.1101/2020.04.19.20071357: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   NIH rigor criteria are not applicable to paper type.

   Table 2: Resources

   Experimental Models: Cell Lines
   Sentences	Resources
   One corresponds to primary human lung epithelium (NHBE) and the other to transformed lung alveolar cells (A549).	A549 suggested: NCI-DTP Cat# A549, RRID:CVCL_0023)
   Software and Algorithms
   Sentences	Resources
   The expression dataset is publicly available at GEO (Gene Expression Omnibus) under the accession number GSE48348.18 In this dataset, a total of 11 individuals with LOY were identified.	Gene Expression Omnibus suggested: (Gene Expression Omnibus (GEO, RRID:SCR_005012)
   Array quality was assessed using arrayQualityMetrics Bioconductor package.	arrayQualityMetrics suggested: (arrayQualityMetrics, RRID:SCR_001335) Bioconductor suggested: (Bioconductor, RRID:SCR_006442)
   Differential expression (DE) between individuals with and without LOY was then performed using limma Bioconductor package.	limma suggested: (LIMMA, RRID:SCR_010943)
   Significant DE genes at p<0.001 level were selected for Gene Ontology (GO) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis with clusterProfiler Bioconductor package.	KEGG suggested: (KEGG, RRID:SCR_012773) clusterProfiler suggested: (clusterProfiler, RRID:SCR_016884)
   All statistical analyses were performed using the statistical software R version 3.6.3 (http://www.r-project.org).	http://www.r-project.org suggested: (R Project for Statistical Computing, RRID:SCR_001905)

   ---

   Results from OddPub: Thank you for sharing your data.

   ---

   Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

   ---

   Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
   

   Identifier	Status	Title
   NCT04326920	Completed	Sargramostim in Patients With Acute Hypoxic Respiratory Fail…

   ---

   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

   ---

   Results from JetFighter: We did not find any issues relating to colormaps.

   ---

   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

   ---

   Read the original source
3. 

   Version published to 10.1101/2020.04.19.20071357v1 on medRxiv

   Apr 24, 2020