Serum Mycoplasma pneumoniae IgG in COVID-19: A Protective Factor
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Abstract
Background
A correlation between prior exposure to Mycoplasma pneumoniae (IgG positive) and better clinical response to COVID-19 was elusive.
Methods
A retrospective review of all COVID-19 infected patients treated at Wuhan Union Hospital from Feb 1 to Mar 20 was carried out. Continuous variables were described as mean, median, and interquartile range (IQR), while categorical variables were compared by X2 test or Fisher’s exact test between COVID-19 infected patients with mycoplasma lgG (-) and mycoplasma lgG (+).
Results
Statistically significant differences were shown in terms of laboratory test results. COVID-19 infected patients with mycoplasma lgG positivity had a higher lymphocyte count and percentage (p=0.026, p=0.017), monocyte count and percentage (p=0.028, p=0.006) and eosinophil count and percentage (p=0.039, p=0.007), and a lower neutrophil count and percentage (p=0.044, p=0.006) than COVID-19 infected patients without mycoplasma lgG. Other routine blood tests, including coagulation tests, blood biochemistry and infection-related biomarkers did not significantly differ except for thrombin time (p=0.001) and lactate dehydrogenase (p=0.008). Furthermore, requirement and use of a nasal catheter or oxygen mask was significantly lower in COVID-19 infected patients with mycoplasma lgG positivity (p=0.029).
Conclusions
Our findings indicate that mycoplasma IgG positivity is a potential protective factor for SARS-CoV-2 infection.
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SciScore for 10.1101/2020.04.12.20060079: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This retrospective study was approved by The Institutional Review Board at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication Contamination: Continuous variables were described as mean, median, and interquartile range (IQR), while categorical variables were compared by X2 test or Fisher’s exact test between COVID-19 infected patients with mycoplasma lgG (-) and mycoplasma lgG (+). Table 2: Resources
Software and Algorithms Sentences Resources SPSS version 23.0 was used for all statistical … SciScore for 10.1101/2020.04.12.20060079: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This retrospective study was approved by The Institutional Review Board at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication Contamination: Continuous variables were described as mean, median, and interquartile range (IQR), while categorical variables were compared by X2 test or Fisher’s exact test between COVID-19 infected patients with mycoplasma lgG (-) and mycoplasma lgG (+). Table 2: Resources
Software and Algorithms Sentences Resources SPSS version 23.0 was used for all statistical analyses. SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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