Dynamic profile of severe or critical COVID-19 cases
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Abstract
In December 2019, a cluster of acute respiratory illness, now known as SARS-CoV-2 pneumonia, occurred in Wuhan, China. World Health Organization (WHO) declared the rapidly spreading coronavirus outbreak a pandemic on March 11, 2020, acknowledging what has seemed clear for some time — the virus will likely spread to all countries on the globe. As of February 11, 2020, the Chinese Center for Disease Control and Prevention (China CDC) has officially reported that there are 2.0% (889) asymptomatic cases, 2.3% (1,023) death cases, and 80.9% mild cases among 44,672 confirmed cases. 51.4% (22,981) were male and 48.6% (21,691) were female. Lymphopenia, in particular T lymphopenia, was common among patients with SARS-COV-2 in the observation. A notable drop in CD4 and CD8 lymphocyte counts occurred early in the course of the syndrome and was associated with adverse outcomes. The appearing a phenomenon of lymphocyte depletion (PLD) suggested severe adverse outcomes. The outcome observed: 60% had discharged and 20% had die.
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SciScore for 10.1101/2020.03.18.20038513: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This case series was approved by the institutional ethics board of Shanghai University of Medicine & Health Sciences (#2019-LCHZ-18-20190507).
Consent: Written informed consent was waived due to the rapid emergence of this infectious disease.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Bovine serum albumin (BSA), and goat anti-human IgG and IgM antibodies, rabbit IgG and goat anti-rabbit IgG antibodies, and 50 nm gold nanoparticle (AuNP) colloids (753645) were obtained from Sigma-Aldrich. goat anti-human IgGsuggested: Noneanti-human IgGsuggeste…SciScore for 10.1101/2020.03.18.20038513: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This case series was approved by the institutional ethics board of Shanghai University of Medicine & Health Sciences (#2019-LCHZ-18-20190507).
Consent: Written informed consent was waived due to the rapid emergence of this infectious disease.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Bovine serum albumin (BSA), and goat anti-human IgG and IgM antibodies, rabbit IgG and goat anti-rabbit IgG antibodies, and 50 nm gold nanoparticle (AuNP) colloids (753645) were obtained from Sigma-Aldrich. goat anti-human IgGsuggested: Noneanti-human IgGsuggested: NoneIgMsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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