Time-varying transmission dynamics of Novel Coronavirus Pneumonia in China

  1. Tao Liu
  2. Jianxiong Hu
  3. Jianpeng Xiao
  4. Guanhao He
  5. Min Kang
  6. Zuhua Rong
  7. Lifeng Lin
  8. Haojie Zhong
  9. Qiong Huang
  10. Aiping Deng
  11. Weilin Zeng
  12. Xiaohua Tan
  13. Siqing Zeng
  14. Zhihua Zhu
  15. Jiansen Li
  16. Dexin Gong
  17. Donghua Wan
  18. Shaowei Chen
  19. Lingchuan Guo
  20. Yan Li
  21. Limei Sun
  22. Wenjia Liang
  23. Tie Song
  24. Jianfeng He
  25. Wenjun Ma

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Abstract

Rationale

Several studies have estimated basic production number of novel coronavirus pneumonia (NCP). However, the time-varying transmission dynamics of NCP during the outbreak remain unclear.

Objectives

We aimed to estimate the basic and time-varying transmission dynamics of NCP across China, and compared them with SARS.

Methods

Data on NCP cases by February 7, 2020 were collected from epidemiological investigations or official websites. Data on severe acute respiratory syndrome (SARS) cases in Guangdong Province, Beijing and Hong Kong during 2002-2003 were also obtained. We estimated the doubling time, basic reproduction number ( R 0 ) and time-varying reproduction number ( R t ) of NCP and SARS.

Measurements and main results

As of February 7, 2020, 34,598 NCP cases were identified in China, and daily confirmed cases decreased after February 4. The doubling time of NCP nationwide was 2.4 days which was shorter than that of SARS in Guangdong (14.3 days), Hong Kong (5.7 days) and Beijing (12.4 days). The R 0 of NCP cases nationwide and in Wuhan were 4.5 and 4.4 respectively, which were higher than R 0 of SARS in Guangdong ( R 0 =2.3), Hongkong ( R 0 =2.3), and Beijing ( R 0 =2.6). The R t for NCP continuously decreased especially after January 16 nationwide and in Wuhan. The R 0 for secondary NCP cases in Guangdong was 0.6, and the R t values were less than 1 during the epidemic.

Conclusions

NCP may have a higher transmissibility than SARS, and the efforts of containing the outbreak are effective. However, the efforts are needed to persist in for reducing time-varying reproduction number below one.

At a Glance Commentary

Scientific Knowledge on the Subject

Since December 29, 2019, pneumonia infection with 2019-nCoV, now named as Novel Coronavirus Pneumonia (NCP), occurred in Wuhan, Hubei Province, China. The disease has rapidly spread from Wuhan to other areas. As a novel virus, the time-varying transmission dynamics of NCP remain unclear, and it is also important to compare it with SARS.

What This Study Adds to the Field

We compared the transmission dynamics of NCP with SARS, and found that NCP has a higher transmissibility than SARS. Time-varying production number indicates that rigorous control measures taken by governments are effective across China, and persistent efforts are needed to be taken for reducing instantaneous reproduction number below one.

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    SciScore for 10.1101/2020.01.25.919787: (What is this?)

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    Table 1: Rigor

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    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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  2. Version published to 10.1101/2020.01.25.919787v2 on bioRxiv
  3. Version published to 10.1101/2020.01.25.919787v1 on bioRxiv