MICROBIAL MODULATION THERAPY FOR CANCER PATIENTS- A SYSTEMATIC REVIEW AND A PERSPECTIVE

Background Microbial Modulation therapy has become known as a favorable attachment in cancer treatment, mainly in the head and neck region (HNC). The oral and gut microbiomes play a significant role in regulating immune actions, tumor progression, and treatment results. Dysbiosis relates to disparity in microbial composition and may cause conditions like mucositis, tumor development, and decreased reactions to radiotherapy. Nevertheless, to eliminate the negative results in cancer patients, different microbial interferences have been explored. These include probiotics, prebiotics, postbiotics, antibiotics, Synbiotics, and fecal microbiota transplantation (FMT) to enhance therapeutic effectiveness. Objective To assess the effect of microbial modulation therapies on HNC patients by inspecting their effects over various treatment plans, the response of their immune system, and overall survival. Results A comparative analysis was held based on various studies analyzing microbial interventions in HNC patients. A comprehensive search identified 180 records from databases and 10 records from registries, leading to a total of 190 records. After removing 50 duplicates, 140 records remained for screening. Additionally, 5 records were excluded due to inaccessibility or irrelevant source type, leaving 135 records for screening.