Changes in Reverse Transcription Polymerase Chain Reaction–positive Severe Acute Respiratory Syndrome Coronavirus 2 Rates in Adults and Children According to the Epidemic Stages
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Abstract
From March 2, 2020, to April 26, 2020, 52,588 reverse transcription polymerase chain reaction (RT-PCR) tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were performed in France, 6490 in children and 46,098 in adults. The rate of RT-PCR–positive SARS-CoV-2 tests for children (5.9%) was always less than that for adults (20.3%) but vary according to the epidemic stage. The risk ratio of RT-PCR–positive SARS-CoV-2 tests for adults compared with children was 3.5 (95% confidence interval: 3.2–3.9) for the whole study period.
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SciScore for 10.1101/2020.05.18.20098863: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Risk ratio and 95% confidence intervals (95% CIs) of RT-PCR–positive SARS-CoV-2 tests for adults compared to children were calculated using Stata SE v13.1 (Statacorp, College Station, TX). Statacorpsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:O…
SciScore for 10.1101/2020.05.18.20098863: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Risk ratio and 95% confidence intervals (95% CIs) of RT-PCR–positive SARS-CoV-2 tests for adults compared to children were calculated using Stata SE v13.1 (Statacorp, College Station, TX). Statacorpsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has several limitations. Our rates of RT-PCR–positive SARS-CoV-2 must take into account that RT-PCR practices were heterogeneous and could have evolved depending on the guidelines and the availability of the tests for adults and children. Even if we cannot rule out that some cases could have escaped our surveillance in our centers and that we did not survey the whole country, our results are consistent with the dynamic of the COVID-19 pandemic in France.6 Finally, the viral load was not available in our study for children and adults. We think that the surveillance of RT-PCR–positive tests in adults and children could be a simple and reliable tool to survey the epidemiology of SARS-CoV-2 infection, allowing to quickly detect any re-emergence of the disease.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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