Detection of the Omicron Variant Virus With the Abbott BinaxNow SARS-CoV-2 Rapid Antigen Assay
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Abstract
We assessed the ability of the BinaxNow rapid test to detect severe acute respiratory syndrome coronavirus 2 antigen from 4 individuals with Omicron and Delta infections. We performed serial dilutions of nasal swab samples, and specimens with concentrations of ≥100 000 copies/swab were positive, demonstrating that the BinaxNow test is able to detect the Omicron variant.
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SciScore for 10.1101/2021.12.22.21268219: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Study procedures were approved by the institutional review board of Mass General Brigham and participants gave consent for specimen testing for research purposes.
Consent: Study procedures were approved by the institutional review board of Mass General Brigham and participants gave consent for specimen testing for research purposes.Sex as a biological variable not detected. Randomization not detected. Blinding The swabs were then tested according to the manufacturer’s instructions and results interpreted by three readers, blinded to the specimen variant and concentration, as positive, negative, or discordant (if not all three readers agreed). Power Analysis not detected. Table 2: Resources
No …
SciScore for 10.1101/2021.12.22.21268219: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Study procedures were approved by the institutional review board of Mass General Brigham and participants gave consent for specimen testing for research purposes.
Consent: Study procedures were approved by the institutional review board of Mass General Brigham and participants gave consent for specimen testing for research purposes.Sex as a biological variable not detected. Randomization not detected. Blinding The swabs were then tested according to the manufacturer’s instructions and results interpreted by three readers, blinded to the specimen variant and concentration, as positive, negative, or discordant (if not all three readers agreed). Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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