Diagnostic Utility of a Ferritin-to-Procalcitonin Ratio to Differentiate Patients With COVID-19 From Those With Bacterial Pneumonia: A Multicenter Study

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1. Version published to 10.1093/ofid/ofab124

   Mar 14, 2021
2. 

   ScreenIT

   Oct 22, 2020

   SciScore for 10.1101/2020.10.20.20216309: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Institutional Review Board Statement	IRB: Ethics statement: This investigation was approved by the Colorado Multiple Institutional Review Board (COMIRB) at the University of Colorado Anschutz Medical Campus (UCHealth), the Institutional Review Board (IRB) at Phoebe Putney Memorial Hospital in Albany, Georgia (USA), and the IRB at Yichang Central People’s Hospital of China Three Gorges University.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Sex as a biological variable	not detected.

   Table 2: Resources

   …

   Software and Algorithms
   Sentences	Resources
   At UCHealth and Phoebe Putney Memorial Hospital, data were retrospectively collected and stored in RedCap (electronic capture tools).

   SciScore for 10.1101/2020.10.20.20216309: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Institutional Review Board Statement	IRB: Ethics statement: This investigation was approved by the Colorado Multiple Institutional Review Board (COMIRB) at the University of Colorado Anschutz Medical Campus (UCHealth), the Institutional Review Board (IRB) at Phoebe Putney Memorial Hospital in Albany, Georgia (USA), and the IRB at Yichang Central People’s Hospital of China Three Gorges University.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Sex as a biological variable	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   At UCHealth and Phoebe Putney Memorial Hospital, data were retrospectively collected and stored in RedCap (electronic capture tools).	RedCap suggested: (REDCap, RRID:SCR_003445)
   Statistical analysis: Statistical analyses were performed using STATA software, version 12.1 (StataCorp, College Station, Texas, USA).	STATA suggested: (Stata, RRID:SCR_012763) StataCorp suggested: (Stata, RRID:SCR_012763)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   This study has several limitations. Proper use of F/P requires obtaining ferritin and PCT simultaneously as soon as possible after clinical presentation. However, our data included the first available levels of ferritin and PCT, and these levels may not have been obtained simultaneously or immediately after initial presentation. The diagnostic characteristics of F/P may improve with use of early and simultaneous acquisition of ferritin and PCT. Our total patient cohort from all 3 hospitals included only 34 patients with bacterial pneumonia, and more bacterial pneumonia cases need to be assessed to obtain a more accurate estimate of the utility of F/P. The retrospective study design makes it susceptible to several biases and the applicability of F/P to other patient populations is uncertain. Due to limitations of available data, we were unable to assess F/P association with important outcomes like mortality, ICU stay, and mechanical ventilation. Although we identified and adjusted for several confounders, there may be confounders unaccounted for in our analysis. Furthermore, we observed F/P overlap at low values for F/P (Fig 1), and our model predicts this is likely due to COVID-19 patients with mild disease. Low F/P in COVID-19 likely associates with smaller amounts of cytolysis and increased inflammation. It may therefore be difficult to separate mild COVID-19 cases with cases of bacterial pneumonia. If our model accurately reflects disease mechanism, serial calculation of F...

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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3. 

   Version published to 10.1101/2020.10.20.20216309v1 on medRxiv

   Oct 22, 2020