Transmission Routes of Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers of a French University Hospital in Paris, France

  1. Adrien Contejean
  2. Jérémie Leporrier
  3. Etienne Canouï
  4. Jacques Fourgeaud
  5. Alice-Andrée Mariaggi
  6. Fanny Alby-Laurent
  7. Emmanuel Lafont
  8. Lauren Beaudeau
  9. Claire Rouzaud
  10. Fabienne Lecieux
  11. Agnès Greffet
  12. Anne-Sophie L’Honneur
  13. Jean-Marc Tréluyer
  14. Fanny Lanternier
  15. Anne Casetta
  16. Pierre Frange
  17. Marianne Leruez-Ville
  18. Flore Rozenberg
  19. Olivier Lortholary
  20. Solen Kernéis

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Abstract

In this case-control study on 564 healthcare workers of a university hospital in Paris (France), contacts without protection with coronavirus disease 2019 (COVID-19) patients or with colleagues were associated with infection with severe acute respiratory syndrome coronavirus 2, whereas working in a COVID-dedicated unit and having children kept in childcare facilities were not.

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  1. ScreenIT

    SciScore for 10.1101/2020.10.30.20223081: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    SARS-CoV-2 serology was determined by the Abbott® SARS-CoV-2 IgG assay, a chemiluminescent microparticle immunoassay intended for the qualitative detection of IgG antibodies to SARS-CoV-2.
    SARS-CoV-2
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    We acknowledge several limitations, in particular recall bias, but cases and controls were interrogated prospectively and shortly after PCR assay. Additionally, our questionnaire included declarative data maybe not fully compressive regarding SARS-CoV-2 exposures. In conclusion, profession category, direct patient care or assignment to a COVID-19-dedicated unit were not associated with COVID-19 infection in our cohort of HCW. Conversely, close contacts with suspected or confirmed COVID-19 patients without PPE or multiplication of contacts with colleagues without mask may be risk factors for COVID-19 infection in HCW. Systematic mask wearing outside home was associated with a reduction of this risk during the pre-lockdown period.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1093/ofid/ofab054
  3. Version published to 10.1101/2020.10.30.20223081v1 on medRxiv