Clinical Symptoms Among Ambulatory Patients Tested for SARS-CoV-2
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Abstract
We compared symptoms and characteristics of 4961 ambulatory patients with and without laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection. Findings indicate that clinical symptoms alone would be insufficient to distinguish between coronavirus disease 2019 and other respiratory infections (eg, influenza) and/or to evaluate the effects of preventive interventions (eg, vaccinations).
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SciScore for 10.1101/2020.10.20.20213272: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This study was approved by institutional review boards at the Centers for Disease Control and Prevention and all participating sites. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:One limitation of this analysis is that only patients meeting screening criteria were included, thus sensitivity and specificity of other research case definitions were not assessed. In addition, symptom lists …
SciScore for 10.1101/2020.10.20.20213272: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This study was approved by institutional review boards at the Centers for Disease Control and Prevention and all participating sites. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:One limitation of this analysis is that only patients meeting screening criteria were included, thus sensitivity and specificity of other research case definitions were not assessed. In addition, symptom lists at some study sites did not assess symptoms commonly reported by outpatients with confirmed COVID-19 (such as fatigue). Because enrollment in this research study occurred after a clinical swab was obtained for testing, some patients might have been aware of their test results at the time of enrollment and symptom assessment, which could have influenced responses to some questions. Finally, persons without COVID-19 (i.e., negative for SARS CoV-2 by RT-PCR) may have had false negative test results; however, to reduce misclassification, cases were classified based on results of molecular assays, and participants were tested within 10 days of illness onset. In addition to establishing clinical criteria for mild illness to evaluate interventions to prevent COVID-19, systematic testing for SARS-CoV-2 and influenza will be needed when both viruses circulate for assessing effectiveness of 2020–2021 seasonal influenza vaccines [4, 9]. Symptom criteria that can be rapidly assessed before enrollment in research studies of influenza and COVID-19 would help ensure systematic testing for both viruses. Sensitivity and specificity of screening criteria including subjective fever, cough, and loss of taste or smell should be assessed among ambulatory persons with COVID-19 for use in epid...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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