Efficient network immunization under limited knowledge

  1. Yangyang Liu
  2. Hillel Sanhedrai
  3. GaoGao Dong
  4. Louis M Shekhtman
  5. Fan Wang
  6. Sergey V Buldyrev
  7. Shlomo Havlin

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Abstract

Targeted immunization of centralized nodes in large-scale networks has attracted significant attention. However, in real-world scenarios, knowledge and observations of the network may be limited, thereby precluding a full assessment of the optimal nodes to immunize (or quarantine) in order to avoid epidemic spreading such as that of the current coronavirus disease (COVID-19) epidemic. Here, we study a novel immunization strategy where only n nodes are observed at a time and the most central among these n nodes is immunized. This process can globally immunize a network. We find that even for small n (≈10) there is significant improvement in the immunization (quarantine), which is very close to the levels of immunization with full knowledge. We develop an analytical framework for our method and determine the critical percolation threshold pc and the size of the giant component P∞ for networks with arbitrary degree distributions P(k). In the limit of n → ∞ we recover prior work on targeted immunization, whereas for n = 1 we recover the known case of random immunization. Between these two extremes, we observe that, as n increases, pc increases quickly towards its optimal value under targeted immunization with complete information. In particular, we find a new general scaling relationship between |pc(∞) − pc(n)| and n as |pc(∞) − pc(n)| ∼ n−1exp(−αn). For scale-free (SF) networks, where P(k) ∼ k−γ, 2 < γ < 3, we find that pc has a transition from zero to nonzero when n increases from n = 1 to O(log N) (where N is the size of the network). Thus, for SF networks, having knowledge of  ≈log N nodes and immunizing the most optimal among them can dramatically reduce epidemic spreading. We also demonstrate our limited knowledge immunization strategy on several real-world networks and confirm that in these real networks, pc increases significantly even for small n.

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  1. Version published to 10.1093/nsr/nwaa229
  2. ScreenIT

    SciScore for 10.1101/2020.04.07.20056606: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

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  3. Version published to 10.1101/2020.04.07.20056606v1 on medRxiv