Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial

  1. Nadine G Rouphael
  2. Angela R Branche
  3. David J Diemert
  4. Ann R Falsey
  5. Cecilia Losada
  6. Lindsey R Baden
  7. Sharon E Frey
  8. Jennifer A Whitaker
  9. Susan J Little
  10. Satoshi Kamidani
  11. Emmanuel B Walter
  12. Richard M Novak
  13. Richard Rupp
  14. Lisa A Jackson
  15. Tara M Babu
  16. Angelica C Kottkamp
  17. Anne F Luetkemeyer
  18. Lilly C Immergluck
  19. Rachel M Presti
  20. Martín Bäcker
  21. Patricia L Winokur
  22. Siham M Mahgoub
  23. Paul A Goepfert
  24. Dahlene N Fusco
  25. Robert L Atmar
  26. Christine M Posavad
  27. Antonia Netzl
  28. Derek J Smith
  29. Kalyani Telu
  30. Jinjian Mu
  31. Lisa J McQuarrie
  32. Mat Makowski
  33. Mamodikoe K Makhene
  34. Sonja Crandon
  35. David C Montefiori
  36. Paul C Roberts
  37. John H Beigel
  38. for the Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team
  39. David J Diemert
  40. Elissa Malkin
  41. Jeffrey M Bethony
  42. Aimee Desrosiers
  43. Marc Siegel
  44. Angela R Branche
  45. Ann R Falsey
  46. Edward Walsh
  47. Patrick Kingsley
  48. Michael Peasley
  49. Nadine G Rouphael
  50. Cecilia Losada
  51. Daniel S Graciaa
  52. Hady Samaha
  53. Paulina A Rebolledo
  54. Zanthia Wiley
  55. Lindsey R Baden
  56. Amy C Sherman
  57. Stephen R Walsh
  58. Alexandra Tong
  59. Rebecca Rooks
  60. Sharon E Frey
  61. Getahun Abate
  62. Zacharoula Oikonomopoulou
  63. Daniel F Hoft
  64. Irene Graham
  65. Jennifer A Whitaker
  66. Hana M El Sahly
  67. Wendy A Keitel
  68. C Mary Healy
  69. Robert L Atmar
  70. Susan J Little
  71. Thomas C S Martin
  72. Nicole Carter
  73. Steven Hendrickx
  74. Evan J Anderson
  75. Christina A Rostad
  76. Satoshi Kamidani
  77. Etza Peters
  78. Emmanuel B Walter
  79. Michael J Smith
  80. M Anthony Moody
  81. Kenneth E Schmader
  82. Richard M Novak
  83. Benjamin G Ladner
  84. Andrea Wendrow
  85. Jessica Herrick
  86. Richard Rupp
  87. Laura Porterfield
  88. Lisa A Jackson
  89. Maya Dunstan
  90. Rebecca Lau
  91. Barbara Carste
  92. Tara M Babu
  93. Anna Wald
  94. Taylor Krause
  95. Kirsten Hauge
  96. Angelica C Kottkamp
  97. Mark J Mulligan
  98. Tamia Davis
  99. Celia Engelson
  100. Vijaya Soma
  101. Anne F Luetkemeyer
  102. Chloe Harris
  103. Azquena Munoz Lopez
  104. Lilly C Immergluck
  105. Erica Johnson
  106. Austin Chan
  107. Rachel M Presti
  108. Jane A O’Halloran
  109. Ryley M Thompson
  110. Martín Bäcker
  111. Andrew B Fleming
  112. Sajumon Joseph
  113. Patricia L Winokur
  114. Jeffery Meier
  115. Jack Stapleton
  116. Siham M Mahgoub
  117. Celia Maxwell
  118. Sarah Shami
  119. Paul A Goepfert
  120. Dahlene N Fusco
  121. Arnaud C Drouin
  122. Florice K Numbi
  123. Kirsten E Lyke
  124. David S Stephens
  125. Kathleen M Neuzil
  126. Monica M Farley
  127. Jeanne Marrazzo
  128. Sidnee Paschal Young
  129. Jeffery Lennox
  130. Robert L Atmar
  131. Linda McNeil
  132. Elizabeth Brown
  133. Christine M Posavad
  134. Megan A Meagher
  135. Julie McElrath
  136. Mike Gale
  137. Kuleni Abebe
  138. Mat Makowski
  139. Heather Hill
  140. Jim Albert
  141. Holly Baughman
  142. Lisa McQuarrie
  143. Kalyani Telu
  144. Jinjian Mu
  145. Lisa J McQuarrie
  146. Teri C Lewis
  147. Lisa A Giebeig
  148. Theresa M Engel
  149. Caleb J Griffith
  150. Wendi L McDonald
  151. Alissa E Burkey
  152. Lisa B Hoopengardner
  153. Jessica E Linton
  154. Nikki L Gettinger
  155. David C Montefiori
  156. Amanda Eaton
  157. Derek J Smith
  158. Antonia Netzl
  159. Samuel H Wilks
  160. Sina Türeli
  161. Mamodikoe Makhene
  162. Mohamed Elsafy
  163. Rhonda Pikaart-Tautges
  164. Janice Arega
  165. Binh Hoang
  166. Dan Curtin
  167. Hyung Koo
  168. Elisa Sindall
  169. Sonja Crandon
  170. Marciela M DeGrace
  171. Diane J Post
  172. Seema U Nayak
  173. Paul C Roberts
  174. John H Beigel
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Abstract

We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.

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  1. Version published to 10.1093/infdis/jiad323
  2. Version published to 10.1101/2023.06.06.23290973v1 on medRxiv