Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019
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Abstract
We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.
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SciScore for 10.1101/2020.06.28.20141556: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Serology: Plasma samples were tested for IgG antibodies directed against SARS-CoV-2 nucleocapsid using a CE-marked ELISA (ID.Vet, ID screen® SARS-CoV-2-N, Montpellier, France) as previously described11. IgGsuggested: NoneSoftware and Algorithms Sentences Resources We acquired on a 3-laser, 10-color Navios flow cytometer and analyzed using Kaluza Software version 2.1 (both from Beckman Coulter Brea, CA Inc). Kaluzasuggested: (Kaluza, RRID:SCR_016182)Results from OddPub: We did not detect open …
SciScore for 10.1101/2020.06.28.20141556: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Serology: Plasma samples were tested for IgG antibodies directed against SARS-CoV-2 nucleocapsid using a CE-marked ELISA (ID.Vet, ID screen® SARS-CoV-2-N, Montpellier, France) as previously described11. IgGsuggested: NoneSoftware and Algorithms Sentences Resources We acquired on a 3-laser, 10-color Navios flow cytometer and analyzed using Kaluza Software version 2.1 (both from Beckman Coulter Brea, CA Inc). Kaluzasuggested: (Kaluza, RRID:SCR_016182)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04347850 Recruiting A Cohort of Patients With Possible or Confirmed SARS-CoV-2 (… Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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