Modeling the Impact of Vaccination Strategies for Nursing Homes in the Context of Increased Severe Acute Respiratory Syndrome Coronavirus 2 Community Transmission and Variants
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Abstract
Using an agent-based model, we examined the impact of community prevalence, the Delta variant, staff vaccination coverage, and booster vaccines for residents on outbreak dynamics in nursing homes. Increased staff coverage and high booster vaccine effectiveness leads to fewer infections, but cumulative incidence is highly dependent on community transmission.
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SciScore for 10.1101/2021.10.25.21265493: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our results are subject to several limitations. As described previously [5,7], while our model incorporates data on contact structure from nursing homes and separately models contacts between residents and staff, we do not further differentiate between types of contacts. We also do not incorporate any prior infection; we assume that all residents and staff have never been infected, which may underestimate the level of immune protection …
SciScore for 10.1101/2021.10.25.21265493: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our results are subject to several limitations. As described previously [5,7], while our model incorporates data on contact structure from nursing homes and separately models contacts between residents and staff, we do not further differentiate between types of contacts. We also do not incorporate any prior infection; we assume that all residents and staff have never been infected, which may underestimate the level of immune protection (particularly for those who are unvaccinated) in a setting with high rates of past infection. Although they are important endpoints, given limited data and heterogeneity in hospitalization criteria between facilities, we do not model hospitalizations and deaths and instead only distinguish between asymptomatic and symptomatic infection. This may underestimate the impact of vaccines on disease severity, as symptomatic infections among vaccinated individuals may be less severe. Finally, we do not explore the impact of supply shortages in this model. Given the high rate of resident turnover, increasing staff COVID-19 vaccination coverage will require fewer doses in most nursing homes than providing boosters to all vaccinated residents. This may be an important consideration, in situations with limited vaccine supply.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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