Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination

  1. David H Canaday
  2. Oladayo A Oyebanji
  3. Debbie Keresztesy
  4. Michael Payne
  5. Dennis Wilk
  6. Lenore Carias
  7. Htin Aung
  8. Kerri St. Denis
  9. Evan C Lam
  10. Christopher F Rowley
  11. Sarah D Berry
  12. Cheryl M Cameron
  13. Mark J Cameron
  14. Brigid M Wilson
  15. Alejandro B Balazs
  16. Christopher L King
  17. Stefan Gravenstein

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Abstract

Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neutralizing antibodies at or below the assay’s limit of detection.

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  1. Version published to 10.1093/cid/ciab963
  2. ScreenIT

    SciScore for 10.1101/2021.08.15.21262067: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

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  3. Version published to 10.1101/2021.08.15.21262067v3 on medRxiv
  4. Version published to 10.1101/2021.08.15.21262067v2 on medRxiv
  5. Version published to 10.1101/2021.08.15.21262067v1 on medRxiv